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NICE recommendation of acalabrutinib for patients with treatment-naïve CLL
On March 18, 2021, it was announced that the National Institute for Health and Care Excellence (NICE) in England recommend the use of acalabrutinib monotherapy for patients with treatment-naïve chronic lymphocytic leukemia (CLL).
This recommendation is for patients with a TP53 mutation or 17p deletion, or for patients without these mutations but where fludarabine plus cyclophosphamide and rituximab, or bendamustine plus rituximab is unsuitable. As acalabrutinib is administered as a twice daily tablet, the recommendation is of particular benefit during the current COIVD-19 pandemic because patients can self-administer from home.
This recommendation comes after the European approval previously discussed on the Lymphoma Hub.
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